2Introduction: Today, cancer is known as one of the biggest public health problems and the second cause of death in the world, and due to its high prevalence, it is considered as one of the main health problems all over the world. There are many treatment strategies, including chemotherapy, to treat cancer in patients. Chemotherapy is actually the use of antineoplastic drugs alone or in combination with other drugs. Of course, these drugs can also damage the function of healthy cells and cause many side effects. Anthracyclines are one of the most widely class of drugs used in cancer chemotherapy, doxorubicin, daunorubicin, and epirubicin are among the anthracycline drug group, the most widely used of which is doxorubicin, which causes cardiotoxicity in the patients undergoing chemotherapy, and unfortunately, there is no definite and reliable treatment for it. Various strategies have been used to reduce the toxic effects of doxorubicin on non-target tissues, including the use of medicinal plants, diet and various types of long-term exercises with the aim of increasing tissue antioxidant levels. Therefore, determining the appropriate exercise and nutrition program considering the physical conditions for cancer patients who are undergoing chemotherapy treatment is so important. Therefore, the current review study aimed to determine the effects of DOX cytotoxicity on heart tissue and the benefits of regular physical activity and curcumin supplementation were investigated and discussed. Conclusion: The use of curcumin with aerobic exercise is likely to be a potentially useful candidate to protect against the toxicity of blood cells caused by the drug doxorubicin, which is used to prevent the growth and progression of cancer cells in patients

Introduction: Continuous participation in physical activity is essential to maintaining good health and well-being throughout life. Therefore, the present study aimed to determine correlation between parental support and physical activity, children's perception of parental support, social sense and neighborhood environment with child physical activity. Methods: This study was a descriptive-correlational study. The statistical population consisted of 9-11-year-old male and female students in Tehran and their parents (299610). Based on Morgan table, 384 students were selected and 400 questionnaires were distributed through cluster sampling. To collect data, the "Parent-Reported Support for Physical Activity", "International Physical Activity Questionnaire", "Children's Perceptions of Parental Support", "Sense of Community Scale", "Physical Activity Neighborhood Environment Scale", "Physical Activity Questionnaire for Children", were used. Face, content, and construct validity and reliability were measured. SmartPLS 2. 0 M3 software was used for data analysis. Results: There was a significant positive correlation between physical activity of parents (t=2/31, β =0/22) and physical activity of children. However, there was not a significant correlation between parental support for physical activity (t=0/72, β =0/10) sense of community (t=0/83, β =0/09) children's perception of parental support (t=1/93, β =0/26) and neighborhood environment (t=0/05, β =-0/006) with children physical activity. Conclusions: Parents' physical activity and their type of exercise behavior improve children's physical activity. Therefore, it is suggested that family-based physical activity programs be a priority for family programs.